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Mutations in α-Tubulin Confer Dinitroaniline Resistance at a Cost to Microtubule Function
Protozoan microtubules are sensitive to disruption by dinitroanilines, compounds that kill intracellular Toxoplasma gondii parasites without affecting microtubules in vertebrate host cells. We previously isolated a number of resistant Toxoplasma lines that harbor mutations to the α1-tubulin gene. So...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2096588/ https://ncbi.nlm.nih.gov/pubmed/17881728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-04-0379 |
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