Secondary Mutations Correct Fitness Defects in Toxoplasma gondii With Dinitroaniline Resistance Mutations

Dinitroanilines (oryzalin, trifluralin, ethafluralin) disrupt microtubules in protozoa but not in vertebrate cells, causing selective death of intracellular Toxoplasma gondii parasites without affecting host cells. Parasites containing α1-tubulin point mutations are dinitroaniline resistant but show...

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Bibliographic Details
Main Authors: Ma, Christopher, Tran, Johnson, Li, Catherine, Ganesan, Lakshmi, Wood, David, Morrissette, Naomi
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2008
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Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567385/
https://ncbi.nlm.nih.gov/pubmed/18780736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.092494
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