Termination of DNA synthesis by N(6)-alkylated, not 3′-O-alkylated, photocleavable 2′-deoxyadenosine triphosphates

The Human Genome Project has facilitated the sequencing of many species, yet the current Sanger method is too expensive, labor intensive and time consuming to accomplish medical resequencing of human genomes en masse. Of the ‘next-generation’ technologies, cyclic reversible termination (CRT) is a pr...

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Detalhes bibliográficos
Main Authors: Wu, Weidong, Stupi, Brian P., Litosh, Vladislav A., Mansouri, Dena, Farley, Demetra, Morris, Sidney, Metzker, Sherry, Metzker, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095803/
https://ncbi.nlm.nih.gov/pubmed/17881370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm689
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