Termination of DNA synthesis by N(6)-alkylated, not 3′-O-alkylated, photocleavable 2′-deoxyadenosine triphosphates

The Human Genome Project has facilitated the sequencing of many species, yet the current Sanger method is too expensive, labor intensive and time consuming to accomplish medical resequencing of human genomes en masse. Of the ‘next-generation’ technologies, cyclic reversible termination (CRT) is a pr...

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Bibliographic Details
Main Authors: Wu, Weidong, Stupi, Brian P., Litosh, Vladislav A., Mansouri, Dena, Farley, Demetra, Morris, Sidney, Metzker, Sherry, Metzker, Michael L.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095803/
https://ncbi.nlm.nih.gov/pubmed/17881370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm689
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