Epigenetic regulation of leptin affects MMP‐13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention

OBJECTIVE: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. METHODS: DNA methylation in leptin promoter was measured by DNA bisulfite sequencing, and mRNA expression level...

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Autors principals: Iliopoulos, D, Malizos, K N, Tsezou, A
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2007
Matèries:
Extended Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095321/
https://ncbi.nlm.nih.gov/pubmed/17502362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.069377
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