Epigenetic regulation of leptin affects MMP‐13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention

OBJECTIVE: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. METHODS: DNA methylation in leptin promoter was measured by DNA bisulfite sequencing, and mRNA expression level...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Iliopoulos, D, Malizos, K N, Tsezou, A
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2007
Témata:
Extended Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2095321/
https://ncbi.nlm.nih.gov/pubmed/17502362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.069377
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky