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Epigenetic regulation of leptin affects MMP‐13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention
OBJECTIVE: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. METHODS: DNA methylation in leptin promoter was measured by DNA bisulfite sequencing, and mRNA expression level...
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| Główni autorzy: | , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
BMJ Group
2007
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2095321/ https://ncbi.nlm.nih.gov/pubmed/17502362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2007.069377 |
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