Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension

Hyperplasia of pulmonary artery smooth muscle cells (PA-SMCs) is a hallmark pathological feature of primary pulmonary hypertension (PPH). Here we found that PA-SMCs from patients with PPH grow faster than PA-SMCs from controls when stimulated by serotonin or serum and that these effects are due to i...

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Main Authors: Eddahibi, Saadia, Humbert, Marc, Fadel, Elie, Raffestin, Bernadette, Darmon, Michèle, Capron, Frédérique, Simonneau, Gerald, Dartevelle, Philippe, Hamon, Michel, Adnot, Serge
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209526/
https://ncbi.nlm.nih.gov/pubmed/11602621
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