Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis

Two distinct IL-18 neutralizing strategies, i.e. a rabbit polyclonal anti-mouse IL-18 IgG and a recombinant human IL-18 binding protein (rhIL-18BP), were used to treat collagen-induced–arthritic DBA/1 mice after clinical onset of disease. The therapeutic efficacy of neutralizing endogenous IL-18 was...

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Hauptverfasser: Plater-Zyberk, Christine, Joosten, Leo A.B., Helsen, Monique M.A., Sattonnet-Roche, Pascale, Siegfried, Christiane, Alouani, Sami, van de Loo, Fons A.J., Graber, Pierre, Aloni, Shuki, Cirillo, Rocco, Lubberts, Erik, Dinarello, Charles A., van den Berg, Wim B., Chvatchko, Yolande
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2001
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209462/
https://ncbi.nlm.nih.gov/pubmed/11748266
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