IL-18 directly promotes joint inflammation and induces cartilage destruction through IL-1

Eitemau Tebyg

• Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
  gan: Joosten, LAB, et al.
  Cyhoeddwyd: (2005)
• Local interleukin-12 gene transfer promotes conversion of an acute to a chronic destructive murine streptococcal cell wall arthritis
  gan: Joosten, LAB, et al.
  Cyhoeddwyd: (2001)
• Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction
  gan: Joosten, Leo A.B., et al.
  Cyhoeddwyd: (2004)
• Endogenous IL-12p40 is crucial for antigen-induced arthritis and is partly involved in chronic relapsing streptococcal-cell-wall arthritis
  gan: Jacobs, M, et al.
  Cyhoeddwyd: (2003)
• IL-18 blockade is a potential disease-modifying therapy for rheumatoid arthritis
  gan: Plater-Zyberk, C, et al.
  Cyhoeddwyd: (2001)