Reduced activity of 11β-hydroxysteroid dehydrogenase in patients with cholestasis

Enhanced renal sodium retention and potassium loss in patients with cirrhosis is due to activation of mineralocorticoid receptors (MRs). Increased aldosterone concentrations, however, do not entirely explain the activation of MR in cirrhosis. Here, we hypothesize that cortisol activates MRs in patie...

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izdano v:	J Clin Invest
Principais autores:	Quattropani, Cristiana, Vogt, Bruno, Odermatt, Alex, Dick, Bernhard, Frey, Brigitte M., Frey, Felix J.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2001
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11696574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12745
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