Reduced activity of 11β-hydroxysteroid dehydrogenase in patients with cholestasis

Enhanced renal sodium retention and potassium loss in patients with cirrhosis is due to activation of mineralocorticoid receptors (MRs). Increased aldosterone concentrations, however, do not entirely explain the activation of MR in cirrhosis. Here, we hypothesize that cortisol activates MRs in patie...

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Pubblicato in:	J Clin Invest
Autori principali:	Quattropani, Cristiana, Vogt, Bruno, Odermatt, Alex, Dick, Bernhard, Frey, Brigitte M., Frey, Felix J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11696574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12745
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