Reduced activity of 11β-hydroxysteroid dehydrogenase in patients with cholestasis

Enhanced renal sodium retention and potassium loss in patients with cirrhosis is due to activation of mineralocorticoid receptors (MRs). Increased aldosterone concentrations, however, do not entirely explain the activation of MR in cirrhosis. Here, we hypothesize that cortisol activates MRs in patie...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Autores principales:	Quattropani, Cristiana, Vogt, Bruno, Odermatt, Alex, Dick, Bernhard, Frey, Brigitte M., Frey, Felix J.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 2001
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209437/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11696574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12745
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