Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

Transmissible spongiform encephalopathies display long incubation periods at the beginning of which the titer of infectious agents (prions) increases in peripheral lymphoid organs. This “replication” leads to a progressive invasion of the CNS. Follicular dendritic cells appear to support prion repli...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Aucouturier, Pierre, Geissmann, Frédéric, Damotte, Diane, Saborio, Gabriela P., Meeker, Harry C., Kascsak, Regina, Kascsak, Richard, Carp, Richard I., Wisniewski, Thomas
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209385/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544275/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI13155
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