Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

Transmissible spongiform encephalopathies display long incubation periods at the beginning of which the titer of infectious agents (prions) increases in peripheral lymphoid organs. This “replication” leads to a progressive invasion of the CNS. Follicular dendritic cells appear to support prion repli...

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Main Authors: Aucouturier, Pierre, Geissmann, Frédéric, Damotte, Diane, Saborio, Gabriela P., Meeker, Harry C., Kascsak, Regina, Kascsak, Richard, Carp, Richard I., Wisniewski, Thomas
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC209385/
https://ncbi.nlm.nih.gov/pubmed/11544275
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