A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the αvβ3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the β3 integrin gene, which have dysfunctional ost...

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Bibliografske podrobnosti

izdano v:	J Clin Invest
Principais autores:	Feng, Xu, Novack, Deborah V., Faccio, Roberta, Ory, Daniel S., Aya, Kunihiko, Boyer, Martin I., McHugh, Kevin P., Ross, F. Patrick, Teitelbaum, Steven L.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Clinical Investigation 2001
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12040
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