A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function
Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the αvβ3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the β3 integrin gene, which have dysfunctional ost...
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| Publicado no: | J Clin Invest |
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| Principais autores: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12040 |
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