A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the αvβ3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the β3 integrin gene, which have dysfunctional ost...

Celý popis

Podrobná bibliografie

Vydáno v:	J Clin Invest
Hlavní autoři:	Feng, Xu, Novack, Deborah V., Faccio, Roberta, Ory, Daniel S., Aya, Kunihiko, Boyer, Martin I., McHugh, Kevin P., Ross, F. Patrick, Teitelbaum, Steven L.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical Investigation 2001
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12040
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!