A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the αvβ3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the β3 integrin gene, which have dysfunctional ost...

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Bibliografische gegevens
Hoofdauteurs: Feng, Xu, Novack, Deborah V., Faccio, Roberta, Ory, Daniel S., Aya, Kunihiko, Boyer, Martin I., McHugh, Kevin P., Ross, F. Patrick, Teitelbaum, Steven L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC209281/
https://ncbi.nlm.nih.gov/pubmed/11342577
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