A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

Osteoclastic bone resorption requires cell-matrix contact, an event mediated by the αvβ3 integrin. The structural components of the integrin that mediate osteoclast function are, however, not in hand. To address this issue, we generated mice lacking the β3 integrin gene, which have dysfunctional ost...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Feng, Xu, Novack, Deborah V., Faccio, Roberta, Ory, Daniel S., Aya, Kunihiko, Boyer, Martin I., McHugh, Kevin P., Ross, F. Patrick, Teitelbaum, Steven L.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 2001
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11342577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI12040
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