The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin

Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by accelerated aging and early death, frequently from stroke or coronary artery disease. 90% of HGPS cases carry the LMNA G608G (GGC>GGT) mutation within exon 11 of LMNA, activating a splice donor site that...

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Bibliografiske detaljer
Main Authors: McClintock, Dayle, Ratner, Desiree, Lokuge, Meepa, Owens, David M., Gordon, Leslie B., Collins, Francis S., Djabali, Karima
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2092390/
https://ncbi.nlm.nih.gov/pubmed/18060063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001269
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