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Negative selection imparts peptide specificity to the mature T cell repertoire

The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2003
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14504410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1934636100
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