Negative selection imparts peptide specificity to the mature T cell repertoire

The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development...

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Détails bibliographiques

Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC208798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14504410/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.1934636100
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