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Negative selection imparts peptide specificity to the mature T cell repertoire

The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development...

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Hlavní autoři: Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC208798/
https://ncbi.nlm.nih.gov/pubmed/14504410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1934636100
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