Negative selection imparts peptide specificity to the mature T cell repertoire

The T cell αβ receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development...

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Bibliographic Details
Main Authors: Huseby, Eric S., Crawford, Frances, White, Janice, Kappler, John, Marrack, Philippa
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC208798/
https://ncbi.nlm.nih.gov/pubmed/14504410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1934636100
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