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In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM

The independent influences of invariant chain (Ii) and HLA-DM molecules on the array of naturally processed peptides displayed by HLA-DR molecules were studied using transfected cell lines. The absence of Ii led to an altered set of HLA-DR-bound peptides as judged by the discriminating responses of...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Lightstone, Liz, Hargreaves, Roseanna, Bobek, Gabriele, Peterson, Mary, Aichinger, Gerald, Lombardi, Giovanna, Lechler, Robert
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1997
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20855/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159149/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5772
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