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Loss of luminal Ca(2+) activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death

Different forms of ventricular arrhythmias have been linked to mutations in the cardiac ryanodine receptor (RyR)2, but the molecular basis for this phenotypic heterogeneity is unknown. We have recently demonstrated that an enhanced sensitivity to luminal Ca(2+) and an increased propensity for sponta...

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Autori principali: Jiang, Dawei, Chen, Wenqian, Wang, Ruiwu, Zhang, Lin, Chen, S. R. Wayne
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084339/
https://ncbi.nlm.nih.gov/pubmed/17984046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706573104
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