The Cardiac Ryanodine Receptor Luminal Ca(2+) Sensor Governs Ca(2+) Waves, Ventricular Tachyarrhythmias, and Cardiac Hypertrophy in Calsequestrin Null Mice

Cardiac calsequestrin (CASQ2) is commonly believed to serve as the sarcoplasmic reticulum (SR) luminal Ca(2+) sensor. Ablation of CASQ2 promotes spontaneous Ca(2+) waves (SCWs) and catecholaminergic polymorphic ventricular tachycardia (CPVT) upon stress but not at rest. How SCWs and CPVT are trigger...

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Publicado no:Biochem J
Main Authors: Zhang, Jingqun, Chen, Biyi, Zhong, Xiaowei, Mi, Tao, Guo, Ang, Zhou, Qiang, Tan, Zhen, Wu, Guogen, Chen, Alexander W, Fill, Michael, Song, Long-Sheng, Chen, S.R. Wayne
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4277184/
https://ncbi.nlm.nih.gov/pubmed/24758151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20140126
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