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Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis

Phosphorylation of the cytoplasmic tyrosine residues of the epidermal growth factor receptor (EGFR) upon binding of EGF induces recognition of various intracellular signaling molecules, including Grb2. Here, the reaction kinetics between EGFR and Grb2 was analyzed by visualizing single molecules of...

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Detalhes bibliográficos
Main Authors: Morimatsu, Miki, Takagi, Hiroaki, Ota, Kosuke G., Iwamoto, Ryo, Yanagida, Toshio, Sako, Yasushi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084288/
https://ncbi.nlm.nih.gov/pubmed/17991782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701330104
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