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Single-molecule analysis of epidermal growth factor binding on the surface of living cells
Global cellular responses induced by epidermal growth factor (EGF) receptor (EGFR) occur immediately with a less than 1% occupancy among tens of thousands of EGFR molecules on single cell surface. Activation of EGFR requires the formation of a signaling dimer of EGFR bound with a single ligand to ea...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1570442/ https://ncbi.nlm.nih.gov/pubmed/16946702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601308 |
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