Single-Molecule Observation of the Ligand-Induced Population Shift of Rhodopsin, A G-Protein-Coupled Receptor

Rhodopsin is a G-protein-coupled receptor, in which retinal chromophore acts as inverse-agonist or agonist depending on its configuration and protonation state. Photostimulation of rhodopsin results in a pH-dependent equilibrium between the active state (Meta-II) and its inactive precursor (Meta-I)....

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Autors principals: Maeda, Ryo, Hiroshima, Michio, Yamashita, Takahiro, Wada, Akimori, Nishimura, Shoko, Sako, Yasushi, Shichida, Yoshinori, Imamoto, Yasushi
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2014
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945020/
https://ncbi.nlm.nih.gov/pubmed/24559994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.01.020
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