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mTOR is the Rapamycin-Sensitive Kinase that Confers Mechanically-Induced Phosphorylation of the Hydrophobic Motif Site Thr(389) in p70(S6k)

Mechanical stretch induces phosphorylation of the hydrophobic motif site Thr389 in p70(S6k) through a rapamycin-sensitive (RS) pathway that involves a unique PI3K-independent mechanism. Rapamycin is considered to be a highly specific inhibitor of the protein kinase mTOR; however, mTOR is also consid...

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Bibliografiska uppgifter
Huvudupphovsmän: Hornberger, Troy Alan, Sukhija, Kunal Balu, Wang, Xiao-Rong, Chien, Shu
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084087/
https://ncbi.nlm.nih.gov/pubmed/17825298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.08.045
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