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PKCθ promotes c-Rel–driven mammary tumorigenesis in mice and humans by repressing estrogen receptor α synthesis
The vast majority of primary human breast cancer tissues display aberrant nuclear NF-κB c-Rel expression. A causal role for c-Rel in mammary tumorigenesis has been demonstrated using a c-Rel transgenic mouse model; however, tumors developed with a long latency, suggesting a second event is needed to...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2007
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2082145/ https://ncbi.nlm.nih.gov/pubmed/18037997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32424 |
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