Running Promotes Wakefulness and Increases Cataplexy in Orexin Knockout Mice

STUDY OBJECTIVE: People with narcolepsy and mice lacking orexin/hypocretin have disrupted sleep/wake behavior and reduced physical activity. Our objective was to identify physiologic mechanisms through which orexin deficiency reduces locomotor activity. DESIGN: We examined spontaneous wheel running...

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Main Authors: España, Rodrigo A., McCormack, Sarah L., Mochizuki, Takatoshi, Scammell, Thomas E.
Format: Artigo
Jezik:Inglês
Izdano: Associated Professional Sleep Societies, LLC 2007
Teme:
Orexin Knockout
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2082091/
https://ncbi.nlm.nih.gov/pubmed/18041476
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