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Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)

Selenoprotein biosynthesis is mediated by tRNA(Sec), which inserts selenocysteine at UGA codons in a complex, context-specific manner. This opal suppressor serves in the conversion of serine to selenocysteine as well. The mouse tRNA(Sec) gene (Trsp) maps to a proximal segment of chromosome 7. We con...

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Autores principales: Bösl, Michael R., Takaku, Kazuaki, Oshima, Masanobu, Nishimura, Susumu, Taketo, Makoto M.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20812/
https://ncbi.nlm.nih.gov/pubmed/9159106
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