Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp)

Selenoprotein biosynthesis is mediated by tRNA(Sec), which inserts selenocysteine at UGA codons in a complex, context-specific manner. This opal suppressor serves in the conversion of serine to selenocysteine as well. The mouse tRNA(Sec) gene (Trsp) maps to a proximal segment of chromosome 7. We con...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Bösl, Michael R., Takaku, Kazuaki, Oshima, Masanobu, Nishimura, Susumu, Taketo, Makoto M.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9159106/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.11.5531
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