Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects
Ras proteins control a complex intracellular signaling network. Gain-of-function mutations in RAS genes lead to RASopathy disorders in humans, including Noonan syndrome (NS). NS is the second most common syndromic cause of congenital heart disease. Although conditional expression of the NrasG12D/+ m...
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| Автори: | , , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Frontiers Media S.A.
2021-02-01
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| Серія: | Frontiers in Cell and Developmental Biology |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/articles/10.3389/fcell.2021.633661/full |
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