The Distal Sequence Element of the Selenocysteine tRNA Gene Is a Tissue-Dependent Enhancer Essential for Mouse Embryogenesis

Appropriate expression of the selenocysteine tRNA (tRNA(Sec)) gene is necessary for the production of an entire family of selenoprotein enzymes. This study investigates the consequence of disrupting an upstream enhancer region of the mouse tRNA(Sec) gene (Trsp) known as the distal sequence element (...

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Main Authors: Kelly, Vincent P., Suzuki, Takafumi, Nakajima, Osamu, Arai, Tsuyoshi, Tamai, Yoshitaka, Takahashi, Satoru, Nishimura, Susumu, Yamamoto, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084291/
https://ncbi.nlm.nih.gov/pubmed/15831471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3658-3669.2005
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