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Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP)

Picornavirus infectivity is dependent on the RNA poly(A) tail, which binds the poly(A) binding protein (PABP). PABP was reported to stimulate viral translation and RNA synthesis. Here, we studied encephalomyocarditis virus (EMCV) and poliovirus (PV) genome expression in Krebs-2 and HeLa cell-free ex...

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Bibliografische gegevens
Hoofdauteurs: Svitkin, Yuri V., Costa-Mattioli, Mauro, Herdy, Barbara, Perreault, Sandra, Sonenberg, Nahum
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2080607/
https://ncbi.nlm.nih.gov/pubmed/17942745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.606407
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