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Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

To examine the physiological role of the Fyn tyrosine kinase in neurons, we generated transgenic mice that expressed a fyn cDNA under the control of the calcium/calmodulin-dependent protein kinase IIα promoter. With this promoter, we detected only low expression of Fyn in the neonatal brain. In cont...

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Autores principales: Kojima, Nobuhiko, Wang, Jian, Mansuy, Isabelle M., Grant, Seth G. N., Mayford, Mark, Kandel, Eric R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC20798/
https://ncbi.nlm.nih.gov/pubmed/9114065
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