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Transgenic rescue of insulin receptor–deficient mice

The role of different tissues in insulin action and their contribution to the pathogenesis of diabetes remain unclear. To examine this question, we have used genetic reconstitution experiments in mice. Genetic ablation of insulin receptors causes early postnatal death from diabetic ketoacidosis. We...

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Detalles Bibliográficos
Main Authors: Okamoto, Haruka, Nakae, Jun, Kitamura, Tadahiro, Park, Byung-Chul, Dragatsis, Ioannis, Accili, Domenico
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC449751/
https://ncbi.nlm.nih.gov/pubmed/15254588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421645
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