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Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver

Although recombinant adenovirus vectors offer a very efficient means by which to transfer genetic information into cells in vivo, antigen-dependent immunity limits the duration of gene expression and prevents retreatment. Recombinant murine CTLA4Ig and anti-CD40 ligand antibody block costimulatory i...

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Autori principali: Kay, Mark A., Meuse, Leonard, Gown, Allen M., Linsley, Peter, Hollenbaugh, Diane, Aruffo, Alejandro, Ochs, Hans D., Wilson, Christopher B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC20785/
https://ncbi.nlm.nih.gov/pubmed/9114052
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