Classification of mutations in the human CD40 ligand, gp39, that are associated with X-linked hyper IgM syndrome.

The interaction between the T cell activation antigen gp39 and CD40, its receptor CD40 on B cells, plays a critical role in the regulation of humoral immune responses. Using a detailed three-dimensional model of the gp39 extracellular region, we have analyzed 20 mutations in gp39 that were, with one...

Full description

Saved in:
Bibliographic Details
Main Authors: Bajorath, J., Seyama, K., Nonoyama, S., Ochs, H. D., Aruffo, A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1996
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143372/
https://ncbi.nlm.nih.gov/pubmed/16509032
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items