Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice

The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), likely functions in multiple signaling pathways. Here, we report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis. The mutant mice exhibit massive neurodegeneration, particularly in th...

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Autors principals: Zhang, Yanling, Zolov, Sergey N., Chow, Clement Y., Slutsky, Shalom G., Richardson, Simon C., Piper, Robert C., Yang, Baoli, Nau, Johnathan J., Westrick, Randal J., Morrison, Sean J., Meisler, Miriam H., Weisman, Lois S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077288/
https://ncbi.nlm.nih.gov/pubmed/17956977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702275104
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