Osmotic stress–induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P(2)) was first identified as a nonabundant phospholipid whose levels increase in response to osmotic stress. In yeast, Fab1p catalyzes formation of PtdIns(3,5)P(2) via phosphorylation of PtdIns(3)P. We have identified Vac14p, a novel vacuolar protei...

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Autores principales: Bonangelino, Cecilia J., Nau, Johnathan J., Duex, Jason E., Brinkman, Mikala, Wurmser, Andrew E., Gary, Jonathan D., Emr, Scott D., Weisman, Lois S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173454/
https://ncbi.nlm.nih.gov/pubmed/11889142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200201002
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