Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice

The signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2)), likely functions in multiple signaling pathways. Here, we report the characterization of a mouse mutant lacking Vac14, a regulator of PI(3,5)P(2) synthesis. The mutant mice exhibit massive neurodegeneration, particularly in th...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Zhang, Yanling, Zolov, Sergey N., Chow, Clement Y., Slutsky, Shalom G., Richardson, Simon C., Piper, Robert C., Yang, Baoli, Nau, Johnathan J., Westrick, Randal J., Morrison, Sean J., Meisler, Miriam H., Weisman, Lois S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2077288/
https://ncbi.nlm.nih.gov/pubmed/17956977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702275104
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados