Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48(DDB2) and p53
Tumor suppressor p53 controls cell cycle progression and apoptosis following DNA damage, thus minimizing carcinogenesis. Mutations in the human DDB2 gene generate the E subgroup of xeroderma pigmentosum (XP-E). We report here that XP-E strains are defective in UV irradiation-induced apoptosis due to...
Tallennettuna:
| Julkaisussa: | Mol Cell Biol |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Taylor & Francis
2003
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7540-7553.2003 |
| Tagit: |
Ei tageja, Lisää ensimmäinen tagi!
|