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Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48(DDB2) and p53

Tumor suppressor p53 controls cell cycle progression and apoptosis following DNA damage, thus minimizing carcinogenesis. Mutations in the human DDB2 gene generate the E subgroup of xeroderma pigmentosum (XP-E). We report here that XP-E strains are defective in UV irradiation-induced apoptosis due to...

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Udgivet i:Mol Cell Biol
Principais autores: Itoh, Toshiki, O'Shea, Cristin, Linn, Stuart
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560002/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7540-7553.2003
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