Impaired Regulation of Tumor Suppressor p53 Caused by Mutations in the Xeroderma Pigmentosum DDB2 Gene: Mutual Regulatory Interactions between p48(DDB2) and p53

Tumor suppressor p53 controls cell cycle progression and apoptosis following DNA damage, thus minimizing carcinogenesis. Mutations in the human DDB2 gene generate the E subgroup of xeroderma pigmentosum (XP-E). We report here that XP-E strains are defective in UV irradiation-induced apoptosis due to...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Itoh, Toshiki, O'Shea, Cristin, Linn, Stuart
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207631/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560002/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7540-7553.2003
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