Human Artificial Chromosomes with Alpha Satellite-Based De Novo Centromeres Show Increased Frequency of Nondisjunction and Anaphase Lag

Human artificial chromosomes have been used to model requirements for human chromosome segregation and to explore the nature of sequences competent for centromere function. Normal human centromeres require specialized chromatin that consists of alpha satellite DNA complexed with epigenetically modif...

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Detalhes bibliográficos
Main Authors: Rudd, M. Katharine, Mays, Robert W., Schwartz, Stuart, Willard, Huntington F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207596/
https://ncbi.nlm.nih.gov/pubmed/14560014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7689-7697.2003
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