Human Artificial Chromosomes with Alpha Satellite-Based De Novo Centromeres Show Increased Frequency of Nondisjunction and Anaphase Lag

Human artificial chromosomes have been used to model requirements for human chromosome segregation and to explore the nature of sequences competent for centromere function. Normal human centromeres require specialized chromatin that consists of alpha satellite DNA complexed with epigenetically modif...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Mol Cell Biol
Principais autores:	Rudd, M. Katharine, Mays, Robert W., Schwartz, Stuart, Willard, Huntington F.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Taylor & Francis 2003
Fag:	DNA Dynamics and Chromosome Structure
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560014/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7689-7697.2003
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