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Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

Ceramide is generated in response to numerous stress-inducing stimuli and has been implicated in the regulation of diverse cellular responses, including cell death, differentiation, and insulin sensitivity. Recent evidence indicates that ceramide may regulate these responses by inhibiting the stimul...

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Detalhes bibliográficos
Main Authors: Powell, Darren J., Hajduch, Eric, Kular, Gursant, Hundal, Harinder S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207567/
https://ncbi.nlm.nih.gov/pubmed/14560023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7794-7808.2003
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