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Remodelling of the SUR–Kir6.2 interface of the K(ATP) channel upon ATP binding revealed by the conformational blocker rhodamine 123

ATP-sensitive K(+) channels (K(ATP) channels) are metabolic sensors formed by association of a K(+) channel, Kir6, and an ATP-binding cassette (ABC) protein, SUR, which allosterically regulates channel gating in response to nucleotides and pharmaceutical openers and blockers. How nucleotide binding...

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Detalhes bibliográficos
Main Authors: Hosy, Eric, Dérand, Renaud, Revilloud, Jean, Vivaudou, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075286/
https://ncbi.nlm.nih.gov/pubmed/17510180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134288
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