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Remodelling of the SUR–Kir6.2 interface of the K(ATP) channel upon ATP binding revealed by the conformational blocker rhodamine 123
ATP-sensitive K(+) channels (K(ATP) channels) are metabolic sensors formed by association of a K(+) channel, Kir6, and an ATP-binding cassette (ABC) protein, SUR, which allosterically regulates channel gating in response to nucleotides and pharmaceutical openers and blockers. How nucleotide binding...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Science Inc
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2075286/ https://ncbi.nlm.nih.gov/pubmed/17510180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.134288 |
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