Effects of L-type Ca(2+) channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome 3

Ventricular arrhythmogenesis in long QT 3 syndrome (LQT3) involves both triggered activity and re-entrant excitation arising from delayed ventricular repolarization. Effects of specific L-type Ca(2+) channel antagonism were explored in a gain-of-function murine LQT3 model produced by a ΔKPQ 1505–150...

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Main Authors: Thomas, Glyn, Gurung, Iman S, Killeen, Matthew J, Hakim, Parvez, Goddard, Catharine A, Mahaut-Smith, Martyn P, Colledge, William H, Grace, Andrew A, Huang, Christopher L-H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2075124/
https://ncbi.nlm.nih.gov/pubmed/17110414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.121921
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